https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47415 Wed 14 Jun 2023 13:52:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18946 + currents could be a key model component requiring improvement to produce the longer-lasting bursting APs. Of the delayed rectifying K⁺ currents family it is of interest that KCNQ and hERG channels have been reported to be gestationally regulated in the uterus. These currents exhibit features similar to the broadly defined uterine I_K1 of the original mathematical model. We thus formulated new quantitative descriptions for several I_KCNQ and I_hERG. Incorporation of these currents into the uterine cell model enabled simulations of the long-lasting bursting APs. Moreover, we used this modified model to simulate the effects of different contributions of I_KCNQ and I_hERG on AP form. Our findings suggest that the alterations in expression of hERG and KCNQ channels can potentially provide a mechanism for fine tuning of AP forms that lends a malleability for changing between plateau-like and long-lasting bursting-type APs as uterine cells prepare for parturition.]]> Wed 11 Apr 2018 09:53:37 AEST ]]>